In 2014, American scientists from Harvard and Stanford University (USA) showed that the use of stem cells isolated from the blood of young mice, restores nerve system of older animals.

Dr. Henne Holstege (Amsterdam, Netherlands), commenting on the secret of healthy longevity of the oldest inhabitant of the planet Hendrik van Andel-Schipper, hypothesized that the aging body can be restored by injection of donor stem cells. And in 2010, researchers from the Jinan University (China) in experimental studies found that the use of placental increase 1.7-fold duration of life of laboratory mice.

Recently the theory of restoration of regenerative potential of the aging organism by infusion of stem cells was confirmed in a clinical trial conducted by the team of scientists from the North-West Medical University n.a. N. Mechnikov, Research Institute of Oncology n.a. NN Petrov and Pokrovsky Stem Cell Bank (St. Petersburg, Russia). The latter is an associate member of the Association of cryobanks.

Russian scientists presented the case of regenerative therapy to a 60 year old patient using a patented method (patent RF № 2350340). Thus, in order to restore the tissue renewal processes of a patient, he was conducted 7 allogeneic transfusions of peripheral blood mononuclear fraction with 2-3 month intervals between them. Mononuclear fraction of peripheral blood is known to contain hematopoietic stem cells. Harvesting of peripheral blood mononuclear fraction was performed from a young donor aged 20 identical to the recipient by gender (male) and antigenic systems: AB0, Rh-factor phenotype, Kell.

Before the start of regenerative therapy and on its background the patient was administered androgen replacement therapy due to the partial androgen deficiency with individually selected dose of the drug testosterone — 1.6 ml of 1% AndroGel once daily in the morning, applied on the skin of the abdomen due to partial androgen deficiency. Three months after the seventh hemotransfusion of mononuclear fraction of peripheral blood, the hematopoietic stem cells CD34 + content in the peripheral blood of a patient increased 5-fold (from 1 to 5 cells in 1 µl). Results were compared with relevant indices of 117 healthy individuals of different age groups and it was shown that the patient after transfusion of mononuclear fraction of peripheral blood from 20 year old donor had hematopoietic stem cell content in peripheral blood close to the maximum value typical for young people. Also, the patient showed an increase in the level of testosterone in blood.

Pluripotent stem cells are a universal mechanism of regeneration, formed in the course of evolution. Age-related decline in the number of pluripotent stem cells interferes with the renewal of tissues, including tissues of endocrine organs. Developing hormonal imbalance aggravates the changes. Mutual burdening of developing pathological processes leads to a vicious circle. Accordingly, people in older age groups have increased risk of cancer, progressive atrophic and sclerotic processes in the majority of tissues, destructive changes in connective tissue (with a reduction of its strength characteristics).

As reported by the study authors under the guidance of Prof. Smolyaninov AB (2014), a transfusion of allogenic pluripotent stem cells in the mononuclear fraction of peripheral blood, harvested from young donors (18-23 years) with the same with recipients gender and blood groups, is a promising way to reverse the development of these pathological processes.

In Ukraine, the Institute of Cell Therapy developed an exclusive program of revitalization based on the use of stem cells and placenta extract for rejuvenation of the body as a whole: without the use of drugs and surgical interventions. Rejuvenation technology, developed by the Institute of Cell Therapy, provides a pronounced cosmetic effect, improves functional activity of internal organs, increases antioxidant protection.