We suggest you read the article published in the journal Cell and Organ Transplantology, 2013,Vol. 1, No. 1

A quite number of patients with global developmental delay (GDD) or mental retardation (MR) have chromosomal abnormalities. Comprehensive rehabilitation therapy helps improve the clinical functions of the patients, but there is no fundamental treatment option for GDD or MR. Umbilical cord blood transplantation (UCBT) showed its safety and efficacy through a lot of animal studies and some clinical trials to date. Erythropoietin (EPO) is an option for adjunctive therapy when combined with cell therapy. We treated a child who had GDD and complex chromosome rearrangement with an allogenic UCBT and concurrent EPO injections, and observed clinical improvements, and confirmed the safety of the procedure.

Jae Sun Shim, Kyounghoon Min, MinYoung Kim

CHA Bundang Medical Center, CHA University, Seongnam-si, Republic of Korea

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