Industry news: the world’s first application of iPS-cells


In September 2014, in Japan the world’s first operation on the application of induced pluripotent stem cells – iPS was conducted.

In 2006, Professor Shinya Yamanaka of Kyoto University for the first time in the world received stem cells from normal human skin cells. The cells were called induced pluripotent stem cells – iPS. In 2012, Shinya Yamanaka and John Gerdon for the discovery of induced pluripotent stem cells were awarded the Nobel Prize.

To date, scientists have learned to grow cells of heart muscle, intestine, pancreas, retina, blood, skin, nerve cells, women’s eggs and sperm from iPS-cells. However, widespread introduction of induced pluripotent stem cells into clinical practice should be preceded by large-scale trials to evaluate the safety and effectiveness of these cells.

Within clinical trials in 2014, scientists took skin cell from a 70-year-old patient with age-related macular degeneration and grew artificial iPS-cells from them. From iPS-derived cells retinal pigment epithelium cells were grown and transplanted to the patient.

The world’s first operation on the transplant of retina grown from artificial multipurpose stem cells (iPS) of the patient appeared to be effective, reported the researchers of RIKEN institute, headed by project manager Masae Takahashi and hospital doctors of the Center for Advanced Medicine at the Japanese Kobe. “From a safety perspective, the past year has shown a positive trend. The events that are harmful to health, within a year were not detected,” – said the representative of the hospital at the Center for Advanced Medicine, Yasuo Kurimoto.

The patient herself admitted that she sees much better, and she is glad that she agreed for the risk of surgery.

Age-related macular degeneration is a serious disease that can lead to complete loss of vision. Only in Japan more than 700 thousand people suffer from it.

Ukrainian scientists also pay considerable attention at the treatment of eye diseases using stem cells. Thus, the Institute of Cell Therapy (Kiev), co-founder and active member of the Association of cryobanks, together with the Institute of Eye Diseases and Tissue Therapy n.a. VP Filatov (Odessa) are working towards the creation of new treatments for eye diseases using cell therapy. Currently, considerable progress in the creation of corneal allografts from placental tissue was achieved, and the positive experience of their clinical application has been accumulated.

According to the materials:

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